Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic

Vandana Singh

January 03, 2025

William Blair has initiated coverage on Denali Therapeutics Inc (NASDAQ:DNLI), a company focused on developing drugs for neurodegenerative diseases.

The analyst highlights that Denali is developing a specialized transport vehicle (TV) platform to enhance the delivery of treatments across the blood-brain barrier.

It stands out from competitors with its promising potential for top-tier performance and scalability across different therapies and conditions.

The company’s lead program Tividenofusp alfa, an enzyme-replacement therapy for Hunter syndrome, shows promise as a best-in-class treatment, the analyst highlights.

William Blair has initiated with an Outperform rating and a fair value of $35 per share.

The company has reached an agreement with the FDA on the requirements for accelerated approval and plans to submit a biologics license application in early 2025.

Insights gained from tividenofusp alfa may also simplify the development and approval process for future treatments targeting other lysosomal storage diseases, such as DNL126 for Sanfilippo syndrome type A.

Most recently, Denali Therapeutics initiated dosing in a global BEACON Phase 2a trial of BIIB122 (DNL151) for LRRK2-associated Parkinson’s disease.

Denali’s market cap stands at $2.93 billion, with an enterprise value of $2.26 billion.

Compared to its peers in neuroscience, rare diseases, and platform biotech, its valuation is lower than some but higher than others, reflecting the strength of its pipeline and technology.

William Blair notes the potential for significant growth as Denali advances its assets, including tividenofusp, which might receive accelerated approval and priority review by late 2025.

If additional clinical data reduces risks associated with its TV-enabled approach, Denali could achieve valuations similar to companies like Avidity Biosciences Inc. (NASDAQ:RNA), Ultragenyx Pharmaceutical Inc. (NASDAQ:RARE), Biogen Inc. (NASDAQ:BIIB), Alnylam Pharmaceuticals, Inc.(NASDAQ:ALNY), and Ionis Pharmaceuticals, Inc. (NASDAQ:IONS).

Price Action: DNLI stock is up 3.17% at $21.50 at the last check on Friday.

Read Next:

Recommended

The Smart Money Copper Trade - Ad

Investing Legend Hints the End May Be Near for These 3 Iconic Stocks - Ad

Trump Signs Law to Launch Dollar 2.0 - Ad

SAN FRANCISCO (AP) — OpenAI CEO Sam Altman has set off a “code red” alert to employees to improve its flagship product, ChatGPT, and delay other product developments, according to The Wall Street Journal.

December Social Security Payments Might Come Early — But There's a Catch

The Social Security Administration is altering its payment schedule for December.

The Next Biggest Bull Run In Over 50 Years

The Next Biggest Bull Run In Over 50 Years - Ad

Gold has hit all-time highs, breaking $4,000 an ounce - but history shows it could be on the verge of its biggest bull run in over half a century... triggered by a likely major event, eerily similar to what happened in the 1970s. (It's NOT inflation or anything you're likely expecting.) Now, a top analyst says you can capture ALL of the upside without touching a risky miner or a boring exchange-traded fund. He sees extraordinary potential gains long term with very little risk.

16 Stocks To Buy If You Want To Escape The AI Hype

Bank of America is pointing investors toward 16 overlooked stocks with strong fundamentals and no direct ties to the AI boom—offering a safer path beyond the hype.

Jim Cramer's '10 Stocks To Own For The Future' In 2000 Cost This Redditor A Decade Of Retirement, Says Having To Work 10 More Years Was 'Painful'

A Reddit user slammed Jim Cramer's stock picks at the peak of the Dot-Com bubble, saying that the CNBC host's suggestions cost him a decade of retirement.

Legally "Skim" $6,361 Into Your Account?

Legally "Skim" $6,361 Into Your Account? - Ad

A former hedge fund manager is now sharing his "Skim Codes" with regular people. They're not stocks. They're not crypto. They're 18-character codes designed to profit from recent market conditions. All you have to do is punch them into an ordinary brokerage account. 84% of these codes have given people the chance to generate cash payouts so far... and his next code is going out any day now.

Here's why everyone's talking about a 'K-shaped' economy

WASHINGTON (AP) — From corporate executives to Wall Street analysts to Federal Reserve officials, references to the “K-shaped economy” are rapidly proliferating.

Adam Schiff Warns Trump Is Dragging America Toward A Venezuela War, Slams GOP For Treating Congress Like An 'Unnecessary Appendage'

Schiff warns that Trump's approach to Venezuela could lead to conflict and Congress must assert its power before it's too late.

First Drug to Show Breakthrough Myocarditis Data. Analysts See Potential 7-10x Upside.

First Drug to Show Breakthrough Myocarditis Data. Analysts See Potential 7-10x Upside. - Ad

This biotech just delivered a medical first in myocarditis and has a Phase 3 trial fully funded into 2027. Wall Street targets imply massive revaluation ahead.

Trump Admin Boasts Affordability Wins As Egg Prices Plunge 86%, Housing Costs Fall Nearly 14%, Despite Rising Grocery Inflation

The Donald Trump administration focuses on affordability for Americans, claiming success in lowering food and housing costs.

Officer Injured By January 6 Predicts Trump Will Flee US After 2026 Elections: 'He'll Be Hopping on That Qatari Jet to Saudi Arabia'

Former District of Columbia Metro police officer Michael Fanone has speculated that President Trump might leave the U.S. after the 2026 elections.

The $43B Big Pharma Story is Starting Over-With a New Player

The $43B Big Pharma Story is Starting Over-With a New Player - Ad

Big Pharma once paid $43B for a small biotech with a similar platform. Now, a new company is following that same playbook, leveraging its patented delivery technology to attract partnerships and near-term revenue potential.

Noem Says National Guard Shooting Suspect Was Radicalized In US

DHS Secretary Kristi Noem says that the suspect in the fatal shooting of a National Guard member in Washington was radicalized domestically.

Elizabeth Warren Calls Trump 'Most Corrupt President' Citing Memecoin, Multi-Million CEO Dinners And Tax Cuts For Billionaires

Sen. Elizabeth Warren (D-Mass.) on Sunday called President Donald Trump’s tenure the “most corrupt” in America’s history, criticizing his involvement in cryptocurrency ventures, meetings with leading industry figures, and other decisions.

Inside: What's Going on Behind the Scenes in DC?

Inside: What's Going on Behind the Scenes in DC? - Ad

Former CIA officer Buck Sexton just met with Trump and VP J.D. Vance - and what he uncovered inside the West Wing is stunning. With ties to Tulsi Gabbard, Mike Johnson, Kash Patel, and more, he's rushing this urgent interview to reveal shocking secrets unfolding behind the scenes right now.

New York advances casinos at a Bronx golf course and near Mets stadium

NEW YORK (AP) — Casinos proposed for a golf course in the Bronx and next to the New York Mets’ ballpark are poised to cash in on a for the New York City area.

Silver Breaks Out In A Short Squeeze, Rising Yields In Japan Hits Stocks and Bitcoin

Rising Yields In Japan

Copper Is Tight, Silver Is Rising - And This Early Nevada Play Hits the Timing Perfectly

Copper Is Tight, Silver Is Rising - And This Early Nevada Play Hits the Timing Perfectly - Ad

AI, electrification, battery storage, and data centers are pushing copper and silver demand sharply higher, even as supply stays tight. This region in Nevada offers rare multi-metal potential, and a new company has secured land in a district the surging district. It's one of the cleanest timing setups in the sector right now.

Donald Trump Administration's Unprecedented Investment In Private Firms Raises Eyebrows

President Trump administration has invested over $10 billion of taxpayer funds in private companies deemed crucial to national security.

How Tyson's Chicken Business Will Offset Beef Weakness

Tyson shares rise as pricing catch-up expected to ease cost pressures; chicken strength offsets beef headwinds amid stable feed costs.

Weiss Gold Veteran Makes Shocking New Call

Weiss Gold Veteran Makes Shocking New Call - Ad

Weiss expert Sean Brodrick went out on a limb last year and declared a historic event would send the yellow metal to $3,150. People laughed at him at the time, but he was off by just two days. Now, Sean has a shocking new prediction for gold ... and reveals a little-known way to get ahead of this bull market.

US futures slip and Asian stocks are mixed, while oil prices surge more than $1 a barrel

BANGKOK (AP) — Asian shares began the week mixed, with Tokyo’s benchmark falling nearly 2% on Monday after the release of data showing weak factory activity, while U.S. futures fell.

Barrick's Breakup Rumors, North America Versus The World

Barrick Mining (NYSE: B) may split into two companies, one focused on North America and another on Africa and Asia.

The Smart Money Copper Trade

The Smart Money Copper Trade - Ad

Only one lines up grade, scale potential, and Quebec power like this. Insider alignment is real. Stepouts are opening new zones. With EVs and grid buildouts rising, this could be the timely copper idea you have been waiting for.

JPMorgan Forecasts Bitcoin Bottom, Anticipates $28.3 Trillion Challenge To Gold By 2026

Analysts at JPMorgan have pinpointed the lowest point of the ongoing Bitcoin (CRYPTO: BTC) price fall and also projected a substantial chall

Silver Soars To Record Highs: It's Up 95% In 2025, The Best Year Since 1979

Silver prices surge over 5% as investors rush to secure metal amid tight supplies and global shortage concerns, driving up stocks and mining equities.

Investing Legend Hints the End May Be Near for These 3 Iconic Stocks

Investing Legend Hints the End May Be Near for These 3 Iconic Stocks - Ad

Futurist Eric Fry say Amazon, Tesla and Nvidia are all on the verge of major disruption. To help protect anyone with money invested in them, he's sharing three exciting stocks to replace them with. He gives away the names and tickers completely free in his brand-new "Sell This, Buy That" broadcast.

Missouri launches sports betting as recent scandals shine a spotlight on the growing industry

JEFFERSON CITY, Mo. (AP) — As Missouri launches sports betting Monday, people will be able to wager on how many points a particular athlete will score in a game — so long as it doesn't involve a Missouri college or university.

California revokes 17,000 driver's licenses. But the state disputes it is over immigration concerns

California plans to revoke 17,000 commercial driver’s licenses given to immigrants after the Trump administration raised concerns about people in the country illegally receiving licenses to drive a semitruck or a bus. But Gov. Gavin Newsom said that isn't the reason.

Trump Signs Law to Launch Dollar 2.0

Trump Signs Law to Launch Dollar 2.0 - Ad

Trump just signed law S.1582, unleashing the biggest money shift in 100+ years. For the first time since 1913, private firms - not the Fed - can mint a "Dollar 2.0." Treasury says it could drain $6.6T from banks and pay 10X current savings rates. Early investors in minting firms could see 40X returns by 2032.

Zohran Mamdani Says No More Thanking Veterans Today, Forgetting Tomorrow — Trump, Obama And Others Express Gratitude For Service

America's top political and tech leaders — including Donald Trump, Barack Obama, Tim Cook, and Sundar Pichai — marked Veterans Day 2025 with tributes honoring the courage and sacrifice of U.S. service members.

Nvidia, Dell, Coinbase, Gorilla Technology And Archer Aviation: Why These 5 Stocks Are On Investors' Radars Today

U.S. stocks closed lower on Monday, with the Dow slipping 1.2% to 46,590.24, the S&P 500 easing 0.92% to 6,672.41, and the Nasdaq dipping 0.84% to 22,708.07. These are the top stocks that gained the attention of retail traders and investors through the day:

The Next Biggest Bull Run In Over 50 Years

The Next Biggest Bull Run In Over 50 Years - Ad

Elon Musk Doubles Down On Solar-Powered AI Satellites, Predicts 'Convergence' Between Tesla, SpaceX, xAI — 'Tesla Is The World Leader In…'

Elon Musk shares plans for solar-powered AI satellites in orbit, touts Tesla as world leader and targets Optimus scale production next year.

Scaramucci Advocates For Market Solutions Amidst Rising Economic Challenges, Says 'People Like Mamdani Will Try And Use Socialist Means To Fix It'

Anthony Scaramucci emphasized the importance of market solutions to address societal issues, warning against potential socialist alternatives.

Legally "Skim" $6,361 Into Your Account?

Legally "Skim" $6,361 Into Your Account? - Ad

Preliminary results in Honduras presidential vote show conservatives ahead of governing party

TEGUCIGALPA, Honduras (AP) — With votes from about 34% of polling places counted in Honduras' , preliminary and partial results released late Sunday showed conservative candidates Nasry Asfura and Salvador Nasralla leading and the governing party trailing, only days after U.S. President in a close race by and announcing that he would pardon .

All 14 victims identified from fiery UPS cargo plane crash in Louisville

LOUISVILLE, Ky. (AP) — A grandfather and his young granddaughter. An electrician with two young children. A woman standing in line at a scrap metal business.

First Drug to Show Breakthrough Myocarditis Data. Analysts See Potential 7-10x Upside.

First Drug to Show Breakthrough Myocarditis Data. Analysts See Potential 7-10x Upside. - Ad

This biotech just delivered a medical first in myocarditis and has a Phase 3 trial fully funded into 2027. Wall Street targets imply massive revaluation ahead.

What to know about the apartment tower fire in Hong Kong

HONG KONG (AP) — Hong Kong firefighters were making a final push to try and find any survivors from the city's , going apartment-to-apartment in the high-rise complex in an exhaustive search.

Trending Now