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Shares Stats
| Shares Outstanding | 157,810,000 |
| Shares Float | 145,550,000 |
| Shares Short | 10,900,000 |
| Insider Holdings | 77% |
| Institution Holdings | 103.20% |
About Ionis Pharmaceuticals Inc
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.
General
| Name | Ionis Pharmaceuticals Inc |
| Ticker | IONS |
| Exchange | NASDAQ |
| Sector | Healthcare |
| Industry | Biotechnology |
| Currency | USD |
| Country | USA |
| Fiscal Year End | December |
| Full Time Employees | 927 |
Highlights
| Analyst Target | 60.75 |
| Market Cap | 4,962,700,000 |
| PEG Ratio | 25.70 |
| EBITDA | -336,270,016 |
Financials
| Curr Year EPS Estimate | -2.55 |
| Next Quarter EPS Estimate | -1.14 |
| Profit Margin | -44.62% |
| Operating Margin | -46.08 |
| Return on Assets | -0.07 |
| Return on Equity | -0.73 |
| Revenue | 803.6M |
| Earnings Per Share | -2.44 |
| Revenue Per Share | 5.50 |
| Gross Profit | -114,912,000 |
| Quarterly Revenue Growth | -0.07 |
Valuation
| Forward PE | 90.91 |
| Price/Sales (Trailing 12 Mt.) | 6.18 |
| Price/Book (Most Recent Quarter) | 7.49 |
Earnings
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