Global Demand for Defense Metals Is Surging 7X
Lithium, uranium and titanium are at the center of a global race. Nations are scrambling to secure them for fighter jets, EVs, and reactors. One N. American project could help fill the West's critical-minerals gap.
Shares Stats
| Shares Outstanding | 146,630,000 |
| Shares Float | 130,460,000 |
| Shares Short | 13,110,000 |
| Insider Holdings | 980% |
| Institution Holdings | 101.36% |
About Denali Therapeutics Inc
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; DNL343 eIF2B activator program for amyotrophic lateral sclerosis; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.
General
| Name | Denali Therapeutics Inc |
| Ticker | DNLI |
| Exchange | NASDAQ |
| Sector | Healthcare |
| Industry | Biotechnology |
| Currency | USD |
| Country | USA |
| Fiscal Year End | December |
| Full Time Employees | 517 |
Highlights
| Analyst Target | 32.00 |
| Market Cap | 2,792,400,000 |
| EBITDA | -542,073,984 |
Financials
| Curr Year EPS Estimate | -2.99 |
| Next Quarter EPS Estimate | -0.77 |
| Return on Assets | -0.27 |
| Return on Equity | -0.44 |
| Earnings Per Share | -2.92 |
| Gross Profit | -420,660,000 |
| Quarterly Revenue Growth | -1 |
Valuation
| Price/Sales (Trailing 12 Mt.) | 3,643.65 |
| Price/Book (Most Recent Quarter) | 2.85 |
Earnings
These 8 Democrats voted with Republicans on the government shutdown deal. Here's how they explain it
WASHINGTON (AP) — The Democratic senators — eight in total — faced almost instant blowback from members of their own party as to allow the Senate to move forward on that would reopen the government.
EPAM Confident On Growth, Initiates $1 Billion Stock Buyback
EPAM Systems (EPAM) stock gained 4.41% after reporting strong third-quarter 2025 results, with sales of $1.394 billion.
Legally "Skim" $6,361 Into Your Account? - Ad
A former hedge fund manager is now sharing his "Skim Codes" with regular people. They're not stocks. They're not crypto. They're 18-character codes designed to profit from recent market conditions. All you have to do is punch them into an ordinary brokerage account. 84% of these codes have given people the chance to generate cash payouts so far... and his next code is going out any day now.
Trump attacks ABC News correspondent Mary Bruce in angry response to three sharp questions
NEW YORK (AP) — President Donald Trump denounced ABC News' Mary Bruce as a “terrible reporter” Tuesday and threatened the network's license to broadcast after she asked him three sharp questions at the White House.
These are the 37 donors helping pay for Trump's $300 million White House ballroom
WASHINGTON (AP) — President Donald Trump says his $300 million White House ballroom will be paid for “100% by me and some friends of mine.”
Why Are 21 Billionaires Moving Their Money ASAP? - Ad
One of the biggest stock market events in 25 years is rapidly unfolding... The economist who predicted the 2008 Financial Crisis says it will be: "The Biggest Crash of Our Lifetime." It could cut the entire tech marketing by HALF.
Wendy's to close hundreds of US stores in bid to halt falling profit
Wendy’s plans to close hundreds U.S. restaurants over the next few months in an effort to boost its profit.
'Rich Dad Poor Dad' Author Robert Kiyosaki Warns Of Crash In BTC, ETH, Gold, Silves Prices, But Says He's Buying, Not Selling: Here's Why
Robert Kiyosaki, author of “Rich Dad Poor Dad,” has shared his investment strategy amid predictions of an economic downturn.
Elon's Optimus to Mint New "Musk Millionaires" as Soon as Jan 26? - Ad
Elon Musk may be set to create more "Musk Millionaires" as soon as January 26... Because on that day, he's expected to officially launch his Optimus robot... An AI-powered robot that Elon himself says will be capable of "doing anything bar nothing". Now, it's important to point out that Elon hasn't released it to the public yet... But ahead of the launch, one Silicon Valley insider has identified a "backdoor way" for any American to invest in Optimus with a regular brokerage account...
JPMorgan Forecasts Bitcoin Bottom, Anticipates $28.3 Trillion Challenge To Gold By 2026
Analysts at JPMorgan have pinpointed the lowest point of the ongoing Bitcoin (CRYPTO: BTC) price fall and also projected a substantial chall
MacKenzie Scott Has Donated More Than $19 Billion, Yet Her Wealth Grows Faster
MacKenzie Scott, the billionaire philanthropist and ex-wife of Amazon founder Jeff Bezos, has donated a staggering $19.25 billion since 2020.
The Market Just Crossed a Dangerous Line - Ad
The man who predicted the 2008 crash and 2020 says today's soaring markets are NOT a bubble - they're something far stranger and more dangerous. He says it's about to change everything you know about money.
AMD, Super Micro Computer, Upstart Holdings, Pinterest And Rivian: Why These 5 Stocks Are On Investors' Radars Today
AMD, SMCI, UPST, PINS, RIVN were among the stocks seen trending on Tuesday, Nov. 4, 2025.
Pizza Hut's parent company says it's considering selling the chain
Pizza Hut could soon be up for sale.
Gold Is Surging Again - But This Nevada Opportunity Offers Much More Than Gold - Ad
Gold has been on an incredible run as investors search for safety, inflation hedges, and real assets with staying power. But this Nevada opportunity isn't just another gold story. The region is showing potential across copper, silver, gold, and tungsten - a rare mix tied to electrification, AI demand, and U.S. supply-chain needs.
Washington's struggling economy takes another economic hit from the government shutdown
WASHINGTON (AP) — With the combination of the , the mass firings of government workers and a , the Capital Area Food Bank in Washington is bracing for the swell of people who will need its help before the holiday season.
TSLA, PLTR, IREN And More: 5 Stocks That Dominated Investor Buzz This Week
Retail investors talked up five hot stocks this week (Nov. 3–7) on X and Reddit's r/WallStreetBets: TSLA, PLTR, MSTR, AMD, IREN.
Buy This Gold Stock Before the New Year - Ad
America is about to see a massive shift in how regular people buy and store gold. Next year, the world's largest gold buyer is expected to launch a new way for everyday Americans to invest in gold with a simple tap on their phone - and it could go live in 2026. When it does, a tiny gold stock trading around $1.60 could explode.
Investigators look into 'repeating bell' heard during takeoff of UPS cargo plane that crashed
LOUISVILLE, Ky. (AP) — A repeating bell sounded in the cockpit for 25 seconds as pilots tried to control a UPS cargo plane that caught fire, had an engine fall off and this week in Louisville, Kentucky, a National Transportation Safety Board member said Friday.
Bitcoin's Crash Below $100,000 Isn't The End: Wall Street Vet Says: 'We Have To Get Through This'
For the first time since July, Bitcoin (CRYPTO: BTC) fell below $100,000 on Tuesday as the crypto sell-off saw $1.7 billion in liquidations in 24 hours.
Trump Signs Law to Launch Dollar 2.0 - Ad
Trump just signed law S.1582, unleashing the biggest money shift in 100+ years. For the first time since 1913, private firms - not the Fed - can mint a "Dollar 2.0." Treasury says it could drain $6.6T from banks and pay 10X current savings rates. Early investors in minting firms could see 40X returns by 2032.
Taylor Swift, Elon Musk, Donald Trump, MrBeast — Robinhood Just Made Their Mojo Tradable
Robinhood has new prediction markets for its customers, with a focus on the entertainment sector. Here are some of the new markets.
Zohran Mamdani's Historic Victory Earns Him Congratulations From Bill Ackman, Bernie Sanders — Trump Wasn't 'On The Ballot,' Says President
Democrats win high-profile races despite Trump's absence and shutdown. Zohran Mamdani elected NYC mayor, Abigail Spanberger wins VA governorship, Mikie Sherrill flips NJ.
America Wants Less Reliance on Foreign Metals - And This Nevada Play Fits the National Shift - Ad
The U.S. is working to reduce dependence on China and Russia for strategic metals like copper, silver, gold, and tungsten. Guardian Metal's recent results confirmed these metals are active in this Nevada corridor - and its stock is up 300%+ YTD. A new explorer on the same belt is entering early as America pivots back to domestic supply.
'No hire' job market leaves unemployed in limbo as threats to economy multiply
WASHINGTON (AP) — When Carly Kaprive left a job in Kansas City and moved to Chicago a year ago, she figured it would take three to six months to find a new position. After all, the 32-year old project manager had never been unemployed for longer than three months.
Trump may become the face of economic discontent, a year after such worries helped him win big
WASHINGTON (AP) — President got a serious that he’s out of touch with their fears about a deteriorating U.S. economy.
Time to Say Goodbye to "Old" Dollar? Say Hello to "Trump's New Dollar" - Ad
If you have any money in U.S. dollars... learn how to prepare for "Trump's new dollar"... Because this could be the biggest change to our financial system in 54 years. President Trump even called it: "The greatest revolution in financial technology since the birth of the internet itself."
Bill.Com Scales Payments Footprint With 33 Million Transactions
Bill Holdings, Inc. (BILL) reports Q1 fiscal 2026 results, beating analyst estimates with adjusted EPS of 61c and revenue of $395.74M.
Tempus AI Stock (TEM) Slides 6% Overnight: Here's Why The Stock Is Trending
Tempus AI shares fell 6.02% in after-hours trading Tuesday following its third-quarter earnings report.
Global Demand for Defense Metals Is Surging 7X - Ad
Lithium, uranium and titanium are at the center of a global race. Nations are scrambling to secure them for fighter jets, EVs, and reactors. One N. American project could help fill the West's critical-minerals gap.
Pfizer clinches deal for obesity drug developer Metsea after a bidding war with Novo Nordisk
NEW YORK (AP) — U.S. pharmaceutical giant Pfizer signed a deal to purchase development-stage obesity drugmaker Metsera Inc., winning a bidding war against Novo Nordisk, the Danish drugmaker behind weight-loss treatments Ozempic and Wegovy.
Buy Now Pay Later Can Torpedo Mortgage Chances
BNPL services like Affirm, Klarna, Afterpay, and PayPal Pay Later are popular but can hurt mortgage approval. Lenders scrutinize bank statements and debt-to-income ratio, and new credit models include BNPL data. Loan officers warn of multiple plans inflating DTI.
Legally "Skim" $6,361 Into Your Account? - Ad
A former hedge fund manager is now sharing his "Skim Codes" with regular people. They're not stocks. They're not crypto. They're 18-character codes designed to profit from recent market conditions. All you have to do is punch them into an ordinary brokerage account. 84% of these codes have given people the chance to generate cash payouts so far... and his next code is going out any day now.
Qatar Airways to sell its holdings in Hong Kong's Cathay Pacific for $896 million
DUBAI, United Arab Emirates (AP) — Qatar Airways will sell its stake in Hong Kong-based Cathay Pacific Airways in a share buyback valued at $896 million, the companies announced, ending the Qatari carrier's .
Deep in Trump country, coal miners with black lung say government is suffocating the 'working man'
OAK HILL, W.Va. (AP) — Lisa Emery loves to talk about her “boys.” With each word, the respiratory therapist’s face softens and shines with pride. But keep her talking, and it doesn’t take long for that passion to switch to hurt. She knows the names, ages, families and the intimate stories of each one’s scarred lungs. She worries about a whole community of West Virginia coal miners — including a growing number in their 30s and 40s — who come to her for help while getting sicker and sicker from what used to be considered an old-timer’s disease: black lung.
Why Are 21 Billionaires Moving Their Money ASAP? - Ad
One of the biggest stock market events in 25 years is rapidly unfolding... The economist who predicted the 2008 Financial Crisis says it will be: "The Biggest Crash of Our Lifetime." It could cut the entire tech marketing by HALF.
Bill Ackman's Amazon Trade Reverses Course – Now Up $119 Million And Counting In Third Quarter
Amazon.com was one of the biggest bets by Bill Ackman in the second quarter. After Q3 earnings, the position is now up since the end of Q2.
Trump Calls for End to Obamacare, Wants Funds To 'Be Sent Directly to the People'
President Trump has called on Senate Republicans to abolish the Affordable Care Act and reroute federal healthcare funds directly to the American people.
Elon's Optimus to Mint New "Musk Millionaires" as Soon as Jan 26? - Ad
Elon Musk may be set to create more "Musk Millionaires" as soon as January 26... Because on that day, he's expected to officially launch his Optimus robot... An AI-powered robot that Elon himself says will be capable of "doing anything bar nothing". Now, it's important to point out that Elon hasn't released it to the public yet... But ahead of the launch, one Silicon Valley insider has identified a "backdoor way" for any American to invest in Optimus with a regular brokerage account...
Zohran Mamdani Was Crypto Bettors' Overwhelming Favorite For New York City Mayor At 100% Odds — And He Just Won
Zohran Mamdani won the high-stakes New York City mayoral race Tuesday, a victory widely anticipated by cryptocurrency bettors, who had overwhelmingly backed the Democratic Socialist.
Information, charts or examples are for illustration and educational purposes only and not for individualized investment management This message contains commercial elements, such as advertising. We only send these offers to those who have opted in to our newsletter. Past performance is not indicative of future results. For these reasons we strongly suggest trading in a DEMO/Simulated account. The information provided by us is for educational and informational purposes only. We make no representations or warranties concerning the products, practices or procedures of any company or entity mentioned or recommended and have not determined if the statements and opinions of the advertiser are accurate, correct or truthful. If you use, act upon or make decisions in reliance on information contained or any external source linked within it, you do so at your own peril and agree to hold us, our officers, directors, shareholders, affiliates and agents without fault.